Journal Articles

Disclaimer: The papers below are intended for private viewing by the page owner or those who otherwise have legitimate access to them. No part of it may in any form or by any electronic, mechanical, photocopying, recording, or any other means be reproduced, stored in a retrieval system or be broadcast or transmitted without the prior permission of the respective publishers. If your organization has a valid subscription of the journals, click on the DOI link for the legitimate copy of the papers.

In vitro replicative fitness of early Transmitted founder HIV-1 variants and sensitivity to Interferon alpha. Sci Rep. (in press)

Plasma metabolic signature and abnormalities in HIV-infected individuals on long-term successful antiretroviral therapy. MetaboliteSep 30;9(10). pii: E210. doi: 10.3390/metabo9100210 [PMID:31574898]

Systemic inflammation and the increased risk of inflamm-aging and age-associated diseases in people living with HIV on long term suppressive antiretroviral therapy. Front. Immunol. https://doi.org/10.3389/fimmu.2019.01965

HIV Elite Control is associated with reduced TRAILshort expression. AIDS, 33(11):1757-1763. [PMID: 31149947).

A viral genome wide association study and genotypic resistance testing in patients failing first line antiretroviral therapy in the first large countrywide Ethiopian HIV cohort. BMC Infect Dis. 2019 Jul 1;19(1):569. [PMID: 31262272]

GS-CA compounds: First-In-Class HIV-1 capsid inhibitors covering multiple grounds. Front Microbiol 10:1227. doi: 10.3389/fmicb.2019.01227 [31312185]

Microfluidic centrifugation assisted precipitation-based DNA quantification.Lab Chip. 2019 Apr 23;19(9):1657-1664. [PMID: 30931470]

HIV-1 subtype C with PYxE insertion has enhanced binding of Gag-p6 to host cell protein ALIX and increased replication fitness. J Virol. Feb 13. pii: JVI.00077-19. doi: 10.1128/JVI.00077-19. [PMID: 30760577]

Mutations in LTR kB transcription factor binding sites in plasma virus among South African people living with HIV-1 (PLHIV). AIDS Res Hum Retroviruses. Feb 22. doi: 10.1089/AID.2018.0293. [PMID: 30793917]

Strain-specific effect on biphasic DNA binding by HIV-1 integrase. AIDS 33(3):588-592. [PMID:30475264].

Characterization of inducible transcription and translation-competent HIV-1 using the RNAscope ISH technology at a single-cell resolution. Front Microbiol 9:2358. doi: 10.3389/fmicb.2018.02358 [PMID: 30333813].

Structural implications of genotypic variations in HIV-1 Integrase From diverse subtypes. Front Microbiol9:1754. doi: 10.3389/fmicb.2018.01754 [PMID: 30116231].

Antiretroviral potency of 4’-Ethnyl-2’-Fluoro-2’-deoxyadenosine, tenofovir alafenamide and second-generation non-nucleoside reverse-transcriptase inhibitors across diverse HIV-1 subtypes. J Antimicrob Chemother, 73(10):2721-2728 [PMID: 30053052].

Unique phenotypic characteristics of recently transmitted HIV-1 subtype C envelope glycoprotein gp120: Use of CXCR6 co-receptor by transmitted founder viruses. J Virol. 92(9). Pii:e00063-18. [PMID: 29491151]

Transcriptomics and targeted proteomics analysis to gain insights into the immune-control mechanisms of HIV-1 infected Elite Controllers. EBioMedicine 27:40-50. [PMID: 29269040] [Featured article]

Plasma soluble factor following two decadesprolonged suppressive antiretroviral therapy in HIV-1 positive males: A cross-sectional study. Medicine (Baltimore), 97(5):e9759. [PMID: 29384862]

Ex vivo antiretroviral potency of newer integrase strand transfer inhibitors cabotegravir and bictegravir in HIV-1 non-B subtypes AIDS 32(4):469-476.[PMID: 29239896]

Pretreatment drug resistance in a large countrywide Ethiopian HIV-1C cohort: a comparison of Sanger and high-throughput sequencing. Sci Rep. 2018 May 15;8(1):7556. [PMID: 29765082]

Analyses of HIV-1 integrase sequences prior toSouth African national HIV-treatment program and available of integrase inhibitors in Cape Town, South Africa. Sci Rep. 2018 Mar 16;8(1):4709. doi: 10.1038/s41598-018-22914-5. [PMID: 29549274]

Phenotypic co-receptor tropism and Maraviroc sensitivity in HIV-1 subtype C from East Africa. Sci Rep. 2018 Feb 5;8(1):2363. [PMID: 29403064]

The microbial metabolite TMAO in 1 association with inflammation and microbial dysregulation in three HIV cohorts at various disease stages. AIDS 32(12):1589-1598.

Quantitative humoral profiling of the HIV-1 proteome in elite controllers and patients with very long-term efficient antiretroviral therapy.Sci Rep. 7(1):666. [PMID: 28386076]

Richer gut microbiota with distinct metabolic profile in HIV infected Elite Controllers. Sci RepJul 24;7(1):6269.[PMID:28740260]

Increased replication capacity following evolution of PYxE insertion in Gag-p6 is associated with enhanced virulence in HIV-1 subtype C from East Africa. J Med Virol. 89(1):106-111 [PMID: 27328744]

A high rate of HIV-1 acquisition post immigration among migrants in Sweden determined by a CD4 T-cell decline trajectory model. HIV Med. 18(9):677-684 [PMID:28444865]

Drug resistance testing through remote genotyping and predicted treatment options in Human Immunodeficiency Virus type 1 infected Tanzanian subjects failing first or second line antiretroviral therapy. PloS One Jun 5;12(6): e0178942.[PMID: 28582463]

Effect of therapy switch on time to second-line antiretroviral treatment failure in HIV-infected patients. PloS One Jul 20;12(7):e0180140. [PMID: 28727795]

Virological failure in patients with HIV-1 subtype C receiving antiretroviral therapy: an analysis of a prospective national cohort in Sweden. Lancet HIV3(4):e166-74 [PMID: 27036992]

Multiplexed next-generation sequencing and de novo assembly to obtain near full-length HIV-1 genome from plasma virus. J Virol Methods 236:98-104 [PMID: 27448822]

Global epidemiology of drug resistance after failure of WHO recommended first-line regimens for adult HIV-1 infection: a multicentre retrospective cohort study.Lancet Infect Dis 16(5):565-575 [PMID: 26831472]

Can HIV reverse transcriptase activity assay be a low cost alternative for viral load monitoring in resource-limited settings? BMJ Open, 6:e008795. [PMID: 26817634]

Phylogenetic analysis of Ethiopian HIV-1 subtype C near full-length genomes reveals high intra-subtype diversity and a strong geographical cluster.AIDS Res Hum Retroviruses 32(5):471-474. [PMID: 26881451]

Mutational heterogeneity in p6 Gag late assembly (L) domains in HIV-1 subtype C viruses from South Africa. AIDS Res Hum Retroviruses32(1):80-4. [PMID: 26413747]

Factors influencing the efficacy of rilpivirine on HIV-1 subtype C in low- and middle-income countries. J Antimicrob Chemother, 71(2):367-71.[PMID: 26518047]

Gut microbiota diversity predicts immune status in HIV-1 infection.AIDS 29(18):2409-18. [PMID: 26355675]

Subtype-independent near full-length HIV-1 genome sequencing and assembly to be used in large molecular epidemiological studies and clinical management. J Int AIDS Soc. 2015 Jun 25;18(1):20035. [PMID: 26115688]

Virological efficacy with first-line antiretroviral treatment in India: predictors of viral failure and evidence of viral resuppression.Trop Med Int Health. 20(11):1462-1472. [PMID: 26146863]

Performance of genotypic tools for prediction of tropism in HIV-1 subtype C V3 loop sequences.Intervirology. 2015 Jan 7;58 (1):1-5. [PMID: 25573618]

Cost-efficient HIV-1 drug resistance surveillance using multiplexed high throughput amplicon sequencing: Implications for use in low and middle-income countries. J Antimicrob Chemother, 69(12):3349-55. [PMID:25085657]

Novel tetra-peptide insertion in Gag p6 ALIX-binding motif in HIV-1 subtype C associated with protease inhibitor failure in Indian patients.AIDS; 28(15): 2319-22. [PMID: 25102091]

Temporal trends in the Swedish HIV-1 epidemic: Increase in non-Bsubtypes and recombinant forms over three decades. PLoS One, 9(6):e99390. doi: 10.1371/journal.pone.0099390. [*Equal contribution] [PMID: 24922326].

Limited evolution but increasing trends of primary non-nucleoside reverse transcriptase inhibitors resistance mutations in therapy naive HIV-1 infected individuals in India. AntivirTher, 19(8): 813-818.[PMID: 24699043]

Phylogenetic characterization of six full-length HIV-1 subtype C molecular clones from three patients: Identification of rare subtype C strains containing two NF-κB motifs in the long terminal repeat. AIDS Res Hum Retroviruses. 30(6): 586-591. [*Equal contribution] [PMID:24387762]

Effect of mobile telephone reminders on treatment outcome in HIV: evidence from a randomised controlled trial in India.BMJ 24;349:g5978. doi: 10.1136/bmj.g5978. [PMID:25742320]

The gp120 protein is a second determinant of increased neurovirulence of Southern African HIV-1C isolates compared to Indian HIV-1C isolates. PLoS One,2014 Sep 4;9(9):e107074. doi: 10.1371/journal.pone.0107074. [PMID: 25188269]

Genetic factors associated with slow progression of HIV among perinatally-infected Indian children. Indian Pediatr. 2014 Oct 8;51(10):801-803. [With Editorial Commentary] [PMID: 25362010]

Genetic architecture of HIV type 1 Nef and Tat from HLA-B57-typed long-term survivors in an Indian cohort of perinatally HIV-infected children. AIDS Res Hum Retroviruses. 29(12):1613-6. [PMID: 24020900]

Human APOBEC3G-mediated hypermutation is associated with antiretroviral therapy failure in HIV-1 subtype C- infected individuals. J Int AIDS Soc16:18472. doi: 10.7448/IAS.16.1.18472. [PMID: 23443042]

Long-term efficacy of first line antiretroviral therapy in Indian HIV-1 infected patients: A longitudinal cohort study. PLoS ONE8(1): e55421. doi:10.1371/journal.pone.0055421. [PMID:23383185]

HIV-1 co-receptor tropism in India: increasing proportion of X4-tropism in subtype C strains over two decades. J Acquir Immune DeficSyndr. 65(4):397-404.[PMID:24189148]

Clade C HIV-1 isolates circulating in Southern Africa exhibit a greater frequency of dicysteine motif-containing Tat variants than those in Southeast Asia and cause increased neurovirulence. Retrovirology 10:61. doi: 10.1186/1742-4690-10-61. [PMID: 23758766]

High concordance of genotypic co-receptor prediction in plasma-viral RNA and pro-viral DNA of HIV-1 subtype C virus: implications in use of whole-blood DNA in resource-limited settings. J Antimicrob Chemother 68(9):2003-2006. [PMID: 23633683]

Effectiveness of first-line antiretroviral therapy and acquired drug resistance among HIV-1-infected children in India. Pediatr Infect Dis J 32: e227–e229. [PMID: 23249907]

High viremia and low level of transmitted drug resistance in anti-retroviral therapy-naïve perinatally-infected children and adolescents with HIV-1 subtype C infection. BMC Infec DisNov 22;12(1):317. [PMID: 23171203]

Molecular epidemiology of HIV-1 subtypes in India: Origin and evolutionary history of the predominant subtype C. PLoS ONE7(6): e39819.doi:10.1371/journal.pone.0039819. [PMID:22768132]

Dried blood spot HIV-1 RNA quantification: A useful tool for viral load monitoring among HIV-infected individuals in India. Indian J Med Res, 136; 956-962. [PMID:23391790]

Genetic characterization of HIV-1 Tat exon 1 from a southern Indian clinical cohort: identification of unique epidemiological signature residues. AIDS Res Hum Retroviruses 28(9): 1152-1156. [PMID: 22236201]

Higher prevalence of predicted X4-tropic strains in perinatally-infected older children with HIV-1 subtype C in India. J Acquir Immune DeficSyndr. 59(4):347-353. [PMID: 22107818]

Multiple NF-κB sites in HIV-1 subtype C LTR confer superior magnitude of transcription and thereby the enhanced viral predominance .J Biol Chem, 28;287(53):44714-35.[PMID: 23132857]

Selection of non-nucleoside reverse transcriptase inhibitor-associated mutations in HIV-1 subtype C: evidence of etravirine cross-resistance. AIDS 25:1123–1126. [PMID:21505320]

Characterizations of HIV-1 subtype C protease gene: selection of L63P mutation in protease inhibitor-naive Indian patients. AIDS Res Hum Retroviruses 27(11):1249-53. [PMID:21453185]

Design of a randomized trial to evaluate the influence of mobile phone reminders on adherence to first line antiretroviral treatment in South India – the HIVIND study protocol. BMC Med Res Methodol. Mar 26;10(1):25. [PMID:20346136]

Naturally occurring polymorphisms and primary drug resistance profile among antiretroviral-naïve individuals in Bangalore, India. AIDS Res Hum Retroviruses 26(10): 1097-1101. [PMID:20836706]

Co-receptor tropism prediction among 1045 Indian HIV-1 subtype C sequences: Therapeutic implications for India. AIDS Res. Ther. 7:24 (21 July 2010) doi:10.1186/1742-6405-7-24. [PMID:20646329]

Diversity of HIV-1 Long Terminal Repeat (LTR) Sequences following Mother-to-Child Transmission in North India. AIDS Res Hum Retroviruses 26(12): 1299-1305. [PMID: 20929348]

Genetic and functional analysis of HIV-1 Rev Responsive Element (RRE) sequences from North-India. AIDS Res. Ther. 7:28. [PMID:20682034]

Genetic analysis of HIV-1 Circulating Recombinant Form 02_AG, B and C subtype-specific envelope sequences from Northern India and their predicted co-receptor usage. AIDS Res. Ther. 2009, 6:28. doi:10.1186/1742-6405-6-28. [PMID:19954551]

Genetic and functional characterization of HIV-1 VprC variants from North India: Presence of unique recombinants with mosaic genomes from B, C and D subtypes within the ORF of Vpr. J. Gen. Virol. ; 90: 2768 – 2776. [*Equal Contributions] [PMID:19605589]

Novel HIV-1 Long Terminal Repeat (LTR) sequences of Subtype B and mosaic inter subtype B/C Recombinants in North India. Arch. Virol. 153(10): 1961-1966. [*Equal Contributions] [PMID: 18818865]