Research

Dr. Ujjwal Neogi Research Lab

The Neogi Research lab aims to identify the molecular mechanism and identify novel biomarkers of natural immune control against viral diseases and immune aging. We aim to identify the components of the immune response that are required for natural immune protection and disease severity that can be translated into the future development of vaccine and antiviral strategies against emerging and re-emerging viruses like human immunodeficiency viruses (HIV), Crimean–Congo hemorrhagic fever (CCHF) viruses, dengue viruses, Zika viruses. Using multi-omics system biology approaches we are interested in understanding how virus rewires host cell metabolism to facilitate optimal viral replication. We combine unbiased multi-omics technologies (transcriptomics, proteomics and metabolomics) with hypothesis-driven approaches (based on our in vitro and ex vivo data) and amalgamate molecular biology, biochemistry, structural biology with advance cell culture system and analysis of patient material, to understand the antiviral defense, it’s association with disease severity and immune aging in viral diseases. It provides new possibilities for therapeutic modulation of immune responses, development of antivirals and vaccines and understands the mechanism of immune-aging in viral infections.

Correlates of immune protection

During the viral infection, a certain proportion of rare individuals show natural protection against the viruses. The induction of the innate immune mechanisms is not pathogen-specific but depends on interactions between the host cell…

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Healthy Aging with HIV

Although early mortality is delayed because of effective combination antiretroviral therapy (cART), people living with HIV (PLWH) need to take medication life-long. The cART has also shifted the spectrum of morbidity towards non-infectious complications such as ….

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HIV-1 drug resistance and treatment response

Antiretroviral therapy (ART) has led to a considerable decrease in AIDS mortality. The emergence of the primary and acquired drug resistance mutations (DRM) poses a significant threat to successful antiretroviral therapy (ART) against HIV-infection.

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COVID-19 Research

Viruses exploit the host metabolic machinery to meet their biosynthetic demands, making these host pathways potential therapeutic targets. We are interested in understanding how SARS-CoV-2 rewire host cell metabolism to facilitate optimal viral replication that...

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  • To understand the mechanisms of natural control of HIV-1 replication by the group of HIV-positive individuals called Elite Controllers.
  • To understand disease pathogenesis in hemorrhagic fever viruses including dengue viruses (DENV), chikungunya viruses (CHIKV), Zika viruses (ZIKV) Crimea Congo Hemorrhagic Fever Virus (CCHFV), and Ebola Viruses using system biology approaches.
  • To understand how virus rewires host cell metabolism to facilitate optimal viral replication in HIV and SARS-CoV-2.
  • To elucidate the underlying mechanism of immune-aging in people living with HIV with long term antiretroviral therapy.
  • To elucidate the metabolic and immune signature on the aspect of metabolic syndrome (MestS) during HIV infection.
  • To type the HIV drug resistance in major and minor viral quasispecies in low- and middle- income countries (South Africa, Cameroon, and India).